What is Picamilon™?

Picamilon is a nutritional combination of n-nicotinoyl uniquely bonded to GABA – gamma aminobutyric acid, first synthesized from nutrients in 1970.

Picamilon is an amazingly powerful compound with antioxidant properties, which has been available for over 25 years. Its primary use has been to support normal structure and function during aging. According to the third party literature, Picamilon has been used for nutritional support in the following situations: fatigue and irritability, depression, decreased energy, misuse of alcohol, and anxiety.

An important benefit of using Picamilon is that it is not a sedative, which means you can use Picamilon and still drive and operate machinery, unlike when using tranquilizers.

Picamilon shows different results at different serving levels. At the lower levels, 50mg 3 times a day, it has been reported to achieve a relaxing nutritional effect. At an increased level, 100 mg 3 times a day, it has been reported to bring about a nutritional stimulation effect and increased endurance. When Picamilon is used at the highest level, (250-300 mg per day) studies have shown it to be more stimulating than Piracetam and to have a more pronounced effect than vinpocetine. Other studies have shown Picamilon has the ability to support blood circulation, and blood supply to the brain, in a manner far superior to the results achieved some other well-known popular nootropics.

The effects of Picamilon are felt quickly; most people notice an impact within an hour and the body usually retains Picamilon for up to six hours. It crosses the blood brain barrier easily, which is why the results are normally experienced so rapidly.

Picamilon has an extremely low toxicity and has shown no carcinogenic properties at these low ingested levels when taken in accordance with directions. In summation, as a nutrient Picamilon is a stimulating relaxant and can produce results more quickly than other nootropics.

Method of Action:

Supports normal cerebral circulation and neural regulation in similar manner to gamma aminobutyric acid (GABA). Picamilon is linked with a change in energy metabolism in neurologic tissue.

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Think clearer, remember more and feel better.

Suggested Serving: Start off with half a tablet (1/2) and increase up to two (2) tablets daily as a dietary supplement. Take with meals.

Notice:

Individual results may vary. You should always consult with your physician before starting this product or any health-related program. Galantamine is currently not recommended for use by young individuals.

Notice:

Individual results may vary. You should always consult with your physician before starting this product or any health-related program. Galantamine is currently not recommended for use by young individuals.

Precautions:

If sensitivity or mild digestive upset occurs, reduce dosage or discontinue use. For adult use only. This product should not be used by those with moderate to severe depression. Do not use if tamper resistant seal is missing or broken. Consult your physician prior to use if you are pregnant or nursing.

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DISCLAIMER

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THESE PRODUCTS ARE NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE. ALL INFORMATION FOR ALL PRODUCTS IS EDUCATIONAL ONLY AND IS TAKEN FROM VARIOUS THIRD PARTY SOURCES, AVAILABLE ON REQUEST. IT DOES NOT AND SHOULD NOT REPLACE THE ADVICE OF YOUR PHYSICIAN. THESE PRODUCTS ARE OFFERED AS DIETARY SUPPLEMENTS ONLY. WE DO NOT ENDORSE OR ADOPT THE INFORMATION AND CLAIMS CONTAINED IN THE THIRD PARTY SOURCES.

 Links:

Journals

Picamilon Enhances Blood Flow
Mirzoian RS; Gan’shina TS Farmakol Toksikol (USSR) Jan-Feb 1989, 52 (1) p23-6
Picamilon, a sodium salt of N-nicotinoyl-gamma-aminobutyric acid, was shown to induce a significant increase of cerebral blood flow in conscious cats. Picamilon was found to inhibit neurogenic spasms of cerebral vessels, that were followed by suppression of tonic activity and reflectory discharges in sympathetic nerves. Picamilon led to restoration of the initial condition of cerebral hemodynamics disturbed by a previous administration of serotonin.
 
Vasoactive agent Picamilon in pigmented retinal abiotrophy.
Davydova G.A.; Mukha A.I., Otdel Patologii Setchatki, Mosk. NI Institut Glaznykh Boleznej, Minzdravmedproma Rossii, Moskva Russian Federation Vestnik Oftalmologii (Russian Federation), 1995, 111/3 (20-22)
Eighty patients with pigmented retinal abiotrophy (PRA) and 20 controls were examined. The perfusion pressure and arteriovenous coefficient are markedly reduced in patients with stages 1-2 PRA, in comparison with controls. Deterioration of the visual function in patients with stages 3-4 PRA vs. that in stages 1-2 was associated with a more marked reduction of the hemodynamic parameters and the status of ocular vessels. Picamilon therapy in a dose of 2 ml of 10% solution once a day intramuscularly for 10 days led to improvement of the visual function and ocular hemodynamics in patients with PRA. Treatment efficacy was higher in patients with disease stages 1-2. Picamilon is recommended for the treatment of patients with PRA.
 
The results of clinical study of the drug Picamilon (an analysis of some data of neurologic and psychiatric clinics)
A. P.huaichenko, R. P. Kruglikova-Lvova, The Pharmacological Committee of the Ministry of Health of USSR, 25, Kropotkinaky per., Moscow! NPO, “Vitamins,” 14 A, Nauchny proezd, Moscow 117246, USSR
The analysis of results of Picamilon clinical investigation in 16 neurologic and psychiatric clinics on 984 patients with various diseases is presented. Picamilon efficiency and good tolerance were established. Picamilon was recommended by the Pharmacological Committee of the Ministry of Health of the USSR for application in medicine for insults therapy, for treatment of transient disorders and chronic insufficiency of blood circulation and also as a tranquillizer without the sedative component and myorelaxation; Picamilon is recommended for asthenic disorders within the limits of different psychical diseases and for treating depressions of old age. As a therapeutic and prophylactic remedy, Picamilon is recommended for rehabilitation of capacity for work and for increasing of stability towards physical and psychological burden. Picamilon is used in narcology in the period of abstinence.
 
Effects of Picamilon on learning and memory in water and radial mazes
G. V. Kovalev, A. G. Voznesensky, V. A. Sazhin, Medical Institute, 1, pavshikh bortsov Sq., Volgograd, 400066, USSR
As compared with piracetam in the dose of 200 mg/kg, Picamilon in the dose of 56 mg/kg caused more pronounced nootropic effects on learning of rats in the water maze and electroshock amnesia under these conditions. Picamilon in the dose of 10 mg/kg enhanced short-term and long-term memory in the 8 arm radial maze. Piracetam in the dose 200 mg/kg had no effect on acquisition of rats in radial maze.
 
Vasoactive agent pikamilon in pigmented retinal abiotrophy
Vestnik Oftalmologii (Russian Federation), 1995, 111/3 (20-22)
Eighty patients with pigmented retinal abiotrophy (PRA) and 20 controls were examined. The perfusion pressure and arteriovenous coefficient are markedly reduced in patients with stages 1-2 PRA, in comparison with controls. Deterioration of the visual function in patients with stages 3-4 PRA vs. that in stages 1-2 was associated with a more marked reduction of the hemodynamic parameters and the status of ocular vessels. Pikamilon therapy in a dose of 2 ml of 10% solution once a day intramuscularly for 10 days led to improvement of the visual function and ocular hemodynamics in patients with PRA. Treatment efficacy was higher in patients with disease stages 1-2. Pikamilon is recommended for the treatment of patients with PRA.
 
Results of pikamilon therapy of patients with open-angle glaucoma
Vestnik Oftalmologii (Russian Federation), 1994, 110/4 (4-7)
Administration of pikamilon, a cerebrovascular and nootropic drug, to patients with primary open-angle glaucoma with normalized intraocular pressure and declining visual function resulted in improvement of the central and peripheral visual fields manifesting by improvement of individual sensitivity threshold, decreased area and intensity of scotomas; the treatment had a favorable effect on light sensitivity and vision acuity in some patients. No noticeable effect on arterial pressure was observed. The drug did not reduce the intraocular pressure.
 
[The characteristics of the retinal absorption of labelled preparations of pikamilon and GABA]
Fiziol Zh (USSR) Mar-Apr 1991, 37 (2) p116-8
The velocity of absorption of GABA and its derivative picamilon carbon-labelled by isolated bovine retina has been studied. It is shown that maximal velocity of GABA and picamilon absorption falls at the second incubation minute, then it decreases. In all the cases the picamilon absorption velocity is higher than the GABA absorption velocity. With an increase of concentration in the incubation medium of the labeled preparation under study the absorption velocity of GABA remains practically unchanged, while that of picamilon slightly increases.
 
[The new cerebrovascular preparation pikamilon]
Farmakol Toksikol (USSR) Jan-Feb 1989, 52 (1) p23-6
Picamilon, a sodium salt of N-nicotinoyl-gamma-aminobutyric acid, was shown to induce a significant increase of cerebral blood flow in conscious cats. Picamilon was found to inhibit neurogenic spasms of cerebral vessels that was followed by suppression of tonic activity and reflectory discharges in sympathetic nerves. Picamilon led to restoration of the initial condition of cerebral hemodynamics disturbed by a previous administration of serotonin.
 
PYCAMILON AND CEBROVASCULAR DISORDERS
Institute Of Pharmacology, 8, Baltiyakaya st., Moscow, 125315, USSR
Pycamilon induces a significant increase in cerebral blood flow in conscious animals. Cerebrovascular effect of pycamilon is more potent and durable than that of GABA (aminalon), nicotinic acid, cinnarizin, nicergolin, xantinolnicotinat, dihydroetgotoxin and papaverin. Under pycamilon action there was observed the reduction in neurogenic spasms of cerebrovascular vessels accompanied by the inhibition of tonic activity and reflectory discharges in sympathetic nerves. Pycamilon recovers the cerebral has disturbed by serotonin.
 
MICROVASCULAR EFFECTS OF PYCAMILON IN THE CORTEX
Institute of Pharmacology, 8, Baltiyskaya st.,Moscow, 125315, USSR
Pycamilon when locally applied at a dose of 0,2 ml of’ 5% solution was found to induce the dilatation of pial arterioles. The most pronounced dilatation was observed in vessels with the initial diameter of 10-20 nm. With arteriole diameter being increased the dilatatory effect of the drug diminished. When differently administered pycamilon causes the increase in cortex blood flow in conscious rats and rabbits.
 
PRECLINICAL STUDY OF THE PYCAMILON INJECTION DRUG
NPO “Vitamins”, 14 A, Nauchny proezd, Moscow 117246, USSR
Pycamilon is an original vasoactive and nootropic drug used in medicine as 0,01 g, 0,02 g, 0,05 g tablets. The new pycamilon drug form has been developed. It represents 5% and 10% solutions for injections in ampules. In experiments on animals the new drug form has been found to possess pronounced cerebrovascular activity and antihypoxic effect as the before studied substance of pycamilon. Pycamilon posesses low toxicity by singular and long administrations, it doesn’t produce any local irritative effects by intramuscular and subcutaneous administrations. Pycamilon has not any negative effect on animal blood vessels. The drug is not an allergen. Pycamilon doesn’t possess any cancerogenic activity.